5′-Hydroxy carvedilol

产品编号：

4103709

规格：	≥95% (HPLC)

CAS NO：

包装规格：

10 MG，50 MG

产品类别：

进口试剂

品牌：	Sigma-Aldrich

优惠价：

产品别名

142227-51-8

5′-Hydroxy carvedilol

5OHC

3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol

5-Hydroxycarvedilol

5′-Hydroxyphenylcarvedilol

BM-140830

5′-OH carvedilol

Carvedilol metabolite M5

5′-Hydroxyphenyl carvedilol

基本信息

Empirical Formula【经验(实验)分子式】	C₂₄H₂₆N₂O₅
Molecular weight	422.47
General description【一般描述】	Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

产品性质

Quality Level【质量水平】	100
Assay【测定】	≥95% (HPLC)
form【形式】	solid
color【颜色】	off-white
solubility【溶解性】	DMSO: soluble, clear, colorless
storage temp.【储存温度】	2-8℃

安全信息

Storage Class Code【储存分类代码】	11 - Combustible Solids
WGK	WGK 3

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