您的位置：首页 > 产品中心 > 981-15-7， 臭椿酮
臭椿酮
Ailanthone
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4103917 | 5 MG | 1780 | |||
| 4103917 | 25 MG | 6510 |
产品别名
981-15-7
臭椿酮
Ailanthone
13,21-Didehydrochaparrinone
Δ13-Dehydrochaparrinone
(1β,11β,12α)-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H24O7 |
| Molecular weight | 376.40 |
| EC number【EC 号】 | 683-145-8 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Ailanthone, natural compound isolated from Ailanthus altissima (Simaroubaceae), is a potent inhibitor of androgen receptor (AR) that blocks activities of full-length AR and AR splice variants. It overcomes MDV3100 (Enzalutamide)-resistance in castration-resistant prostate cancer cell lines. Ailanthone disrupts the interaction between AR and the chaperones HSP90, HSP70, and HSP40, which leads to AR ubiquitination and degradation. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O[C@@H]1C([C@]([C@@]2([C@]3([H])[C@@]1(O)OC2)[C@@](O4)([H])C[C@@]([C@]3(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O)=C |
| InChI | 1S/C20H24O7/c1-8-4-12(21)16(24)18(3)10(8)5-13-19-7-26-20(25,17(18)19)15(23)9(2)11(19)6-14(22)27-13/h4,10-11,13,15-17,23-25H,2,5-7H2,1,3H3/t10-,11-,13+,15+,16+,17+,18+,19+,20-/m0/s1 |
| InChI key | WBBVXGHSWZIJST-RLQYZCPESA-N |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P301 + P330 + P331 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Oral |
| Storage Class Code【储存分类代码】 | 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
