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Amorfrutin A
产品别名
80489-90-3
Amorfrutin A
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H24O4 |
| Molecular weight | 340.41 |
| MDL number | MFCD23703108 |
| General description【一般描述】 | Amorfrutin A is an isoprenoid-substituted benzoic acid natural product. Natural product derived from plant source. |
| Biochem/physiol Actions【生化/生理作用】 | Amorfrutin A exhibits antidiabetic effects. It binds to PPARγ with a Ki of 0.236 μM and activates a PPARγ gene reporter assay with an EC50 value of 0.458 μM. In high-fat diet-induced obese (DIO) mice, Amorfrutin A (100 mg/kg/day) enhanced glucose tolerance and insulin sensitivity, while decreasing plasma triglycerides, free fatty acids, insulin, and glucose concentrations. Amorfrutin A inhibits TNF-α-induced expression of a number of inflammatory genes such as COX-2, IL-1β, MCP-1, MIP-2, MIP-3α, MMP-9, and IL-8 through inhibition of both NF-κB and PPARγ activity with efficacy at 5-20 μM. |
产品性质
| Assay【测定】 | ≥90% (LC/MS-ELSD) |
| form【形式】 | solid |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
