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Anti-acetyl-Histone H2B (Lys24) Antibody

产品编号:4104506
规格:from rabbit, purified by affinity chromatography
包装规格:200 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4104506200 μL6690
产品别名

Anti-acetyl-Histone H2B (Lys24) Antibody

Histone H2B type 3-B, H2B type 12

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Changes in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is primarily acetylated at lysines 5, 12, 15, and 20 (3). Ubiquitylation of Histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4). Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of apoptosis and meiosis (5).
Specificity【特异性】
This antibody recognizes Histone H2B acetylated at Lys24.
Immunogen【免疫原】
Epitope: Acetylated Lys24
KLH-conjugated linear peptide corresponding to human Histone H2B acetylated at Lys24.
Application【应用】
Immunoprecipitation Analysis: 10 μg from a representative lot immunoprecipitated acetyl-Histone H2B (Lys24) from HeLa acid extract.

Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H2B (Lys24) (1:500 dilution).
Use Anti-acetyl-Histone H2B (Lys24) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl-Histone H2B (Lys24) also known as H2BK24Ac, Histone H2B (acetyl K24).
Research Sub Category
Histones
Research Category
Epigenetics & Nuclear Function
Quality【质量】
Evaluated by Western Blot in recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.

Western Blot Analysis: A 1:500 dilution of this antibody detected Histone H2B on 10 µg of recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.
Physical form【外形】
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Analysis Note【分析说明】
Control
Recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
Quality Level【质量水平】
300
biological source【生物来源】
rabbit
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human, rat, mouse
technique(s)
dot blot: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_001019770
UniProt accession no.【UniProt登记号】
Q8N257
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~16 kDa observed
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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