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Anti-Achaete Scute homolog 2 Antibody, clone 8F1
产品别名
Anti-Achaete Scute homolog 2 Antibody, clone 8F1
achaete-scute complex (Drosophila) homolog-like 2, achaete-scute complex homolog 2 (Drosophila), achaete-scute complex homolog-like 2, achaete-scute complex-like 2, achaete-scute complex-like 2 (Drosophila), mammalian achaete/scute homologue 2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells (Tanaka, M., et al., (1997) Dev Biol. 190(10):55-65). |
| Specificity【特异性】 | This antibody recognizes Achaete Scute homolog 2. |
| Immunogen【免疫原】 | His-tagged recombinant protein corresponding to mouse Achaete Scute homolog 2. |
| Application【应用】 | Immunohistochemistry: A previous lot of this antibody was used in immunocytochemistry by an independent laboratory (Van der Flier, et al., 2009). Anti-Achaete Scute homolog 2 Antibody, clone 8F1 is an antibody against Achaete Scute homolog 2 for use in WB, IH. |
| Quality【质量】 | Evaluated by Western Blot in human placenta tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected Achaete Scute homolog 2 on 10 µg of human placenta tissue lysate. |
| Physical form【外形】 | Protein G Purified Format: Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 8F1, monoclonal |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_032580.2 |
| UniProt accession no.【UniProt登记号】 | O35885 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... ASCL2(430) |
产品说明
| Target description【目标描述】 | ~ 20 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
