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Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody
| 产品编号： | 4105298 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody
Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human BAG3. |
| Application【应用】 | Research Sub Category Apoptosis - Additional Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected BAG3 in human cardiac and renal tissues. Research Category Apoptosis & Cancer Detect BAG family molecular chaperone regulator 3 (BAG3) using this Anti-BAG family molecular chaperone regulator 3 (BAG3) Antibody validated for use in Western Blotting, IHC(P). |
| Quality【质量】 | Evaluated by Western Blot in DU145 cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected BAG3 in 10 µg of DU145 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control DU145 cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | rhesus macaque (based on 100% sequence homology), canine (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_004272 |
| UniProt accession no.【UniProt登记号】 | O95817 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... BAG3(9531) |
产品说明
| Target description【目标描述】 | ~74/40 kDa observed. An uncharacterized band may appear at ~65 kDa in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
