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Anti-Cellular Fibronectin antibody, Mouse monoclonal
| 产品编号： | 4106102 |
| 规格： | clone FN-3E2, hybridoma cell culture supernatant |
| 包装规格： | 100 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Cellular Fibronectin antibody, Mouse monoclonal
Anti-FN
Anti-Cold-insoluble globulin
Anti-CIG
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Anti-Cellular Fibronectin antibody, Mouse monoclonal (mouse IgM isotype) is derived from the FN-3E2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the antigens released in culture from a breast cancer cell line. Fibronectin (FN), also known as cold-insoluble globulin (CIG), is an extracellular matrix multi-domain glycoprotein composed of two nearly identical disulphide bound polypeptides. Fibronectin 1 is a glycoprotein, that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. It is mapped to human chromosome 2q35. Cellular fibronectin is produced by various cell types, including fibroblasts, endothelial cells, chondrocytes, synovial cells, and myocytes. |
| Immunogen【免疫原】 | Antigens released in culture from a breast cancer cell line |
| Application【应用】 | Anti-cellular Fibronectin antibody, mouse monocloneal has been used in various immunochemical techniques including immunoblotting (220-260 kDa), immunofluorescence, and immunohistochemistry. Anti-Cellular Fibronectin antibody, Mouse monoclonal has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, haemostasis and thrombosis. It is a ubiquitous and essential component of the extracellular matrix (ECM) and plays a vital role in tissue repair mechanism. |
| Physical form【外形】 | The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains fetal calf serum. |
| Other Notes【其他说明】 | This product is for R&D use only, not for drug, household, or other uses. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | culture supernatant |
| antibody product type | primary antibodies |
| clone【克隆】 | FN-3E2, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~220-260 kDa |
| species reactivity | rat, human, mouse, chicken |
| technique(s) | immunoblotting: suitable immunofluorescence: 1:2,000-1:4,000 using human foreskin fibroblast Hs68 cells immunohistochemistry: suitable |
| isotype【同位素/亚型】 | IgM |
| UniProt accession no.【UniProt登记号】 | P02751 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
