Anti-CNGB1 Antibody, clone 5A5.1

32160702

NA.41

CNGB1, also known as Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated cation channel 4 (CNG4), Cyclic nucleotide-gated cation channel gamma, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-1, or Glutamic acid-rich protein (GARP), and encoded by the gene CNGB1/CNCG2/CNCG3L/CNCG4/RCNC2, is a subunit of cyclic nucleotide-gated (CNG) channels which are nonselective cation channels expressed in retinal and olfactory neurons. The CNG channels play important roles in both visual and olfactory signal transduction. When associated with CNGA1, CNGB1 is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. CNGB1 is localized in the plasma membranes of expressing cells and mediates the ion transport of the channel. Mutations in CNGB1 are associated with the genetic disease retinitis pigmentosa 45 that is a progressive vision disease associated with the loss of rod and cone photoreceptors.

GST-tagged recombinant protein corresponding to human CNGB1.

Research Category
Neuroscience
Detect CNGB1 using this Anti-CNGB1 Antibody, clone 5A5.1 validated for use in western blotting.
Research Sub Category
Developmental Signaling

Evaluated by Western Blotting in Y79 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CNGB1 in 10 µg of Y79 cell lysate.

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Format: Purified

100

mouse

purified immunoglobulin

primary antibodies

5A5.1, monoclonal

human

1 mg/mL

western blot: suitable

IgG1κ

NP_001129111

Q14028

wet ice

~140 kDa observed

Stable for 1 year at 2-8°C from date of receipt.

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12 - Non Combustible Liquids

WGK 1