您的位置：首页 > 产品中心 > Anti-DEPTOR Antibody
Anti-DEPTOR Antibody
| 产品编号： | 4106984 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-DEPTOR Antibody
DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | DEPTOR (DEPDC6, DEP domain-containing protein 6) was recently identified as a novel mTOR-interacting protein whose over-expression in certain cell types represents a new mechanism for activating PI3K/Akt signaling and promoting cell survival. DEPTOR negatively regulates mTORC1 and mTORC2. It has been shown that loss of DEPTOR activates various targets that include p70S6K1, Akt, and SGK1, that leads to cell growth and survival. Little was known about DEPDC6 prior to the discovery of its interactions with mTOR, at which time it was given the new name of DEPTOR (Peterson, T.R., et al. (2009). Cell. 137(5):873-876). |
| Specificity【特异性】 | Other homologies: Primate, Equine, Porcine, Canine, Rat, and Mouse based on 99%, 99%, 98%, 97%, and 96% homology, respectively. This antibody recognizes the DEP domain that contains mTOR-interacting protein DEPTOR. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the DEP domain-containing mTOR-interacting protein of human DEPTOR. Epitope: DEP domain-containing mTOR-interacting protein DEPTOR. |
| Application【应用】 | Anti-DEPTOR Antibody detects level of DEPTOR & has been published & validated for use in WB. Research Category Metabolism Research Sub Category PI3K, Akt, & mTOR Signaling |
| Quality【质量】 | Evaluated by Western Blot in HEK293 cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected DEPTOR in HEK293 cell lysate. |
| Linkage【联系】 | Replaces: 09-463 |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HEK293 cell lyaste |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_073620 |
| UniProt accession no.【UniProt登记号】 | Q8TB45 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~46 kDa observed. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
