Anti-DISC1 Antibody

32160702

NA.41

Disrupted in schizophrenia 1 protein (DISC1) is involved in the regulation of multiple aspects of embryonic and adult neurogenesis. DISC1 may play a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. DISC1 is shown to inhibit the activation of AKT-mTOR signaling upon interaction with CCDC88A. DISC1 is required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Additionally, DISC1 is suggested to regulate the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. DISC1 has been shown to participates in the Wnt-mediated neural progenitor proliferation as a positive regulator and may have a role, together with PCNT, in the microtubule network formation.
DICS1 is highly expressed in the dentate gyrus of the hippocampus. It is also expressed in the temporal and parahippocampal cortices and cells of the white matter. Expression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa.

This antibody recognizes the N-terminus of DISC1.

KLH-conjugated linear peptide corresponding to the N-terminus of human DISC1.
Epitope: N-terminus

Anti-DISC1 Antibody is a highly specific rabbit polyclonal antibody, that targets Disc1 & has been tested in western blotting.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

Evaluated by Western Blotting in NIH/3T3 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected DISC1 in 15 µg of NIH/3T3 cell lysate.

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

Control
NIH/3T3 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

mouse

human (based on 100% sequence homology)

western blot: suitable

Q9NRI5

wet ice

human ... DISC1(27185)

~95 kDa observed. Uncharacterized bands may appear in some lysates. Uniprot describes 8 isoforms ranging between ~37 kDa and ~94 kDa

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 1