您的位置：首页 > 产品中心 > Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8
Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8
产品别名
Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8
Adenocarcinoma-associated antigen, CD326 antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, KS 1/4 antigen, Major gastrointestinal tumor-associated protein GA733-2, antigen identified by monoclonal antibo
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Epithelial Call Adhesion Molecule (EpCAM, CD326) is a transmembrane glycoprotein of approximately 40 kDa. EpCAM was initially identified as a tumor associated marker having high expression in quickly proliferating epithelial tumors. As such, EpCAM has been of significant interest as a means for tumor diagnosis and therapy. EpCAM is also expressed in normal epithelial cells, but in comparatively lower levels. Preliminary studies limited EpCAM’s function to cell-cell adhesion; however more recent studies indicate it to be involved in diverse processes that include cell migration, cell signaling, differentiation and proliferation. |
| Specificity【特异性】 | This antibody recognizes epithelial cell adhesion molecule (EpCAM), specifically on undifferentiated human embryonic stem cells. |
| Immunogen【免疫原】 | HES-3 Cells (Choo, et al. (2008) Stem Cells. Jun;26(6):1454-63) Epitope: Unknown |
| Application【应用】 | This Anti-Epithelial Cell Adhesion Molecule (EpCAM) Antibody, clone 8 is validated for use in FC, IC, WB for the detection of Epithelial Cell Adhesion Molecule (EpCAM). Flow Cytometry Analysis: 0.5 µg from a previous lot detected Epithelial cell adhesion molecule in human embryonic stem cells. Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Ng, V., et al., 2010) Research Sub Category Pluripotent & Early Differentiation Adhesion (CAMs) Research Category Stem Cell Research |
| Quality【质量】 | Evaluated by Immunocytochemistry in human embryonic stem cells. Immunocytochemistry Analysis: 1-10 µg/mL from a previous lot detected epithelial cell adhesion molecule (EpCAM) in human embryonic stem cells. |
| Physical form【外形】 | Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Human embryonic stem cells |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| clone【克隆】 | mab 8, monoclonal |
| species reactivity | human |
| technique(s) | flow cytometry: suitable immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG2aκ |
| NCBI accession no.【NCBI登记号】 | NP_002345.2 |
| UniProt accession no.【UniProt登记号】 | P16422 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 40 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
