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Anti-Fetuin A antibody, Mouse monoclonal

产品编号:4107797
规格:clone FetA-M, purified from hybridoma cell culture
包装规格:25 μL,100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
410779725 μL2270
4107797100 μL5420
产品别名

Anti-Fetuin A antibody, Mouse monoclonal

Alpha-2-Z-globulin

Ba-alpha-2-glycoprotein

Alpha-2-HS-glycoprotein (AHSG)

基本信息
NACRES
NA.41
General description【一般描述】
Fetuin A, also known as Alpha-2-HS-glycoprotein (AHSG), Alpha-2-Z-globulin or Ba-alpha-2-glycoprotein, is a member of the cystatin superfamily of cysteine protease inhibitors. Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver Hepatocytes. It is cleaved into two chains bound by disulfide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Monoclonal Anti-Fetuin A (mouse IgM isotype) is derived from the Fet A-M hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a BALB/C mouse immunized with a synthetic peptide corresponding to the internal region of human AHSG (Fetuin A), conjugated to KLH as immunogen. Fetuin A is a 64 kDa protein, predominantly localized to the blood.
Specificity【特异性】
Monoclonal Anti-Fetuin A specifically recognizes Fetuin A from human plasma.
Immunogen【免疫原】
Synthetic peptide corresponding to human Fution A internal region, conjugated to KLH
Application【应用】
The antibody is recommended for use in various immunological techniques including Immunoblotting, Immunohistochemistry and ELISA.
Biochem/physiol Actions【生化/生理作用】
Fetuin A is consider to be a negative acute-phase reactant and its serum concentration decreases in response to inflammation, compared with normal levels. In addition, it acts as a mineral chaperone to facilitate the transport and removal of potentially proinflammatory and procalcific cargo (waste).Fetuin A plays a major role in numerous diseases and pathophysiological conditions involved with calcium metabolisms.
Fetuin A is a secreted calcium-regulatory glycoprotein produced by liver hepatocytes. It is cleaved into two chains bound by disulphide bonds and inhibits ectopic Ca×PO4 ion precipitation and vascular calcification.
Reduction in the serum fetuin might indicate coronary artery disease. Fetuin is also implicated in insulin resistance and metabolic syndrome. Increased levels of fetuin A is observed in non-alcoholic fatty liver disease.
Physical form【外形】
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
产品性质
biological source【生物来源】
mouse
antibody form【抗体形式】
purified from hybridoma cell culture
antibody product type
primary antibodies
clone【克隆】
FetA-M, monoclonal
species reactivity
human
packaging【包装】
antibody small pack of 25 μL
concentration【浓度】
~1 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using Human serum
isotype【同位素/亚型】
IgM
UniProt accession no.【UniProt登记号】
P02765
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... AHSG(197)
产品说明
Storage and Stability【储存及稳定性】
For continuous use, store at 2-8℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer【免责声明】
Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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