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Anti-FGF23 Antibody, clone 278-2
产品别名
Anti-FGF23 Antibody, clone 278-2
Fibroblast growth factor 23, FGF-23, Phosphatonin, Tumor-derived hypophosphatemia-inducing factor, Fibroblast growth factor 23 N-terminal peptide, Fibroblast growth factor 23 C-terminal peptide
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Fibroblast growth factor 23 (FGF-23) is also called Phosphatonin and Tumor-derived hypophosphatemia-inducing factor. FGF-23 belongs to the heparin-binding growth factors family and has several important functions including: regulation of phosphate homeostasis, inhibition of renal tubular phosphate transport, upregulation of EGR1 expression, regulation of vitamin-D metabolism, and negative regulation of osteoblast differentiation and matrix mineralization. FGF-23 is expressed in osteogenic cells, adult trabecular bone, osteocytes and flattened bone-lining cells (inactive osteoblasts). Defects in FGF23 can lead to autosomal dominant hypophosphataemic rickets (ADHR) and hyperphosphatemic familial tumoral calcinosis (HFTC). |
| Immunogen【免疫原】 | Corresponding to human FGF23. |
| Application【应用】 | Flow Cytometry Analysis: 2 µg from a representative lot detected FGF23 in Jurkat and human PMBC cells. Anti-FGF23 Antibody, clone 278-2 is a mouse monoclonal antibody & validated for use in western blotting. Research Category Signaling Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in human salivary gland tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected FGF23 in 10 µg of human salivary gland tissue lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide. Format: Purified Protein A purified |
| Analysis Note【分析说明】 | Control Human salivary gland tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 278-2, monoclonal |
| species reactivity | human |
| technique(s) | flow cytometry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_065689 |
| UniProt accession no.【UniProt登记号】 | Q9GZV9 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... FGF23(8074) |
产品说明
| Target description【目标描述】 | ~25 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
