Anti-Fn14 Antibody

32160702

NA.41

Fibroblast growth factor 14 (FN14) is a member of the TNF receptor superfamily. FN14 is a receptor for TNFSF12/TWEAK and promotes angiogenesis and the proliferation of endothelial cells. Experiments have shown that FN14 binds to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Additionally, FN14 is a weak inducer of apoptosis in some cell types and may modulate cellular adhesion to matrix proteins. FN14 is suggested to induce liver regeneration and is highly expressed in hepatocellular carcinomas. Furthermore, TWEAK induces liver progenitor cell proliferation, suggesting FN14 may play a role in hepatocyte growth control and liver neoplasia. FN14 is highly expressed in heart, placenta and kidney. Intermediate expression of FN14 has been recorded in lung, skeletal muscle and pancreas.

KLH-conjugated Fc-tagged protein corresponding to human Fn14.

Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected Fn14 in human liver tissue lysate.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected Fn14 in human liver tissue.
Anti-Fn14 Antibody is a highly specific rabbit polyclonal antibody, that targets Fibroblast growth factor 14 & has been tested in western blotting, IHC & Immunofluorescence.
Research Category
Apoptosis & Cancer

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected Fn14 in 15 µg of HepG2 cell lysate.

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

Control
HepG2 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

human

immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable

Q9NP84

wet ice

human ... TNFRSF12A(51330)

~34 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~10 kDa and ~14 kDa

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 2