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Anti-GPVI Antibody
| 产品编号： | 4108395 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-GPVI Antibody
GPVI Antibody, Glycoprotein VI, GPIV, Platelet glycoprotein VI precursor, GP6, Glycoprotein 6
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Glycoprotein 6 (GP6), or glycoprotein VI (GPVI), is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. GP6 is a collagen receptor involved in collagen-induced platelet adhesion and activation, and may contribute to arterial and venous thrombus formation. GP6 is a membrane glycoprotein that plays a crucial role in platelet procoagulant activity and subsequent thrombin and fibrin formation. GP6 is expressed in megakaryocytes and platelets. The signaling pathway of GP6 involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. It has been shown that bleeding disorders such as Bleeding Disorder Platelet-Type 11 (BDPLT11), a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen, is caused by defects in GP6. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of GPVI. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the C-terminus of human GPVI. |
| Application【应用】 | Anti-GPVI Antibody is a highly specific rabbit polyclonal antibody, that targets Glycoprotein 6 & has been tested in western blotting, IHC & Immunofluorescence. Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected GPVI in human heart tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected GPVI in human heart cells. |
| Quality【质量】 | Evaluated by Western Blotting/Peptide Inhibition Assay in A20 cell lysate. Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected GPVI in 15 µg of A20 cell lysate. |
| Linkage【联系】 | Replaces: MABT473 |
| Other Notes【其他说明】 | Antigen Affinity Purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q9HCN6 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~115 kDa observed. Uniprot describes 3 isoforms at ~35 kDa, ~37 kDa, and ~67 kDa |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
