Anti-IL-31 Antibody

32160702

NA.41

Interleukin-31 (IL-31) is a T-cell cytokine that activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 is similar to IL-6 type cytokines and is produced mainly by T helper type 2 cells. The ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor is the mediator of IL-31 activity. These proteins activate the JAK/STAT and the AKT signaling pathways in response to IL-31 binding. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes and expressed highly in epithelial cells. Overexpression of IL-31 in transgenic mice results in the development of pruritis, alopecia, and skin lesions. Mutations of IL-31 in humans may result in atopic dermatitis, suggesting that IL-31 may play a role in skin immunity and may represent a novel target for antipruritic drug development.

This antibody recognizes the N-terminus of IL-31.

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human IL-31.

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected IL-31 in rat skeletal muscle tissue.
Anti-IL-31 Antibody is a highly specific rabbit polyclonal antibody, that targets IL-31 & has been tested in western blotting & IHC.
Research Category
Signaling
Research Sub Category
Developmental Signaling

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: 2.5 µg/mL of this antibody detected IL-31 in 15 µg of RAW264.7 cell lysate.

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified

Control
RAW264.7 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

rabbit

100

affinity isolated antibody

primary antibodies

polyclonal

affinity chromatography

rat, mouse

human (immunogen homology)

immunohistochemistry: suitable
western blot: suitable

Q6EAL8

wet ice

~30 kDa observed. Uncharacterized bands may appear in some lysate(s).

Stable for 1 year at 2-8°C from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 2