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Anti-JMJD8 Antibody
| 产品编号： | 4109406 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-JMJD8 Antibody
JMJD, JmjC domain-containing protein 8, Jumonji domain-containing protein 8
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Covalent modification of histones plays critical role in regulating chromatin structure and transcription. JMJD8 is one member of the family of JmjC domain-containing histone demethylation (JHDM) enzymes. These proteins remove specific methyl marks from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. While two isoforms of JMJD8 have been described, further study is still required to clarify the roles and mechanisms of JMJD8 among other JHDM protein family members. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human JMJD8. |
| Application【应用】 | Anti-JMJD8 Antibody is a Rabbit Polyclonal Antibody for detection of JMJD8 also known as Jumonji domain-containing protein 8 & has been validated in WB. Research Category Epigenetics & Nuclear Function Research Sub Category Histone Modifying Proteins |
| Quality【质量】 | Evaluated by Western Blot in HeLa nuclear extract. Western Blot Analysis: 1 mg/mL of this antibody dected JMJD8 in 10 mg of HeLa nuclear extract. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HeLa nuclear extract |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | horse, pig, human |
| species reactivity (predicted by homology) | rhesus macaque (based on 100% sequence homology), porcine (based on 100% sequence homology), canine (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), equine (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001005920.2 |
| UniProt accession no.【UniProt登记号】 | Q96S16 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~37 kDa observed. Two isoforms with molecular weights of ~34 kDa and ~37 kDa have been described. An uncharacterized band at ~160 kDa may be observed in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
