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Anti-JPH3 Antibody
| 产品编号： | 4109410 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-JPH3 Antibody
Junctophilin-3, JP-3, Junctophilin type 3, Trinucleotide repeat-containing gene 22 protein, JPH3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Junctophilin-3 (JPH3, JP-3), also known as Trinucleotide repeat-containing gene 22 protein (TNRC22), is a single-pass type IV membrane protein belonging to the junctophilin family. Junctophilins are important components of the junctional complexes which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. JPH3 is specifically expressed in brain. A mutation associated with JPH3 is the cause of Huntington disease-like type 2 (HDL2), a neurodegenerative disorder. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of JPH3. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to a sequence near the C-terminus of human JPH3. Epitope: Near C-terminus. |
| Application【应用】 | Anti-JPH3 Antibody is a highly specific rabbit polyclonal antibody, that targets Junctophilin-3 & has been tested in western blotting, IHC & Immunofluorescence. Research Category Neuroscience Research Sub Category Neurodegenerative Diseases Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected JPH3 in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected JPH3 in human brain cells. |
| Quality【质量】 | Evaluated by Western Blotting/Peptide Inhibition Assay in Daudi cell lysate. Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected JPH3 in 15 µg of Daudi cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal antibody in buffer containing PBS with 0.02% sodium azide. Affinity purified. |
| Analysis Note【分析说明】 | Control Daudi cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q8WXH2 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~105 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and ~81 kDa Uncharacterized bands may appear in some lysates. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
