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Anti-LARS Antibody
| 产品编号： | 4109683 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-LARS Antibody
Leucine-tRNA ligase, cytoplasmic, Leucyl-tRNA synthetase, LeuRS
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | LARS is the critical cytoplasmic enzyme that charges the tRNA for leucine to become L-leucyl-tRNA, or tRNA(Leu). LARS is thus critical for protein biosynthesis and LARS is up regulated, like many proteins, in cancer. LARS is localized in the cytoplasm and regulated via acetylation. Interestingly, recent research demonstrates that LARS and other tRNA synthetases play key roles as amino acid cellular sensors in my cellular signaling pathways such as mTOR which regulate cell size, protein translation, and even autophagy. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human LARS near the C-terminus. |
| Application【应用】 | Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LARS in human kidney and human liver tissue. This Anti-LARS Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of LARS. |
| Quality【质量】 | Evaluated by Western Blotting in HUVEC cell lysate. Western Blotting Analysis: 0.2 µg/mL of this antibody detected LARS in 10 µg of HUVEC cell lysate. |
| Other Notes【其他说明】 | Affinity purified |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_064502 |
| UniProt accession no.【UniProt登记号】 | Q9P2J5 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... LARS(51520) |
产品说明
| Target description【目标描述】 | ~140 kDa observed |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
