您的位置：首页 > 产品中心 > Anti-Linear Ubiquitin Antibody, clone LUB9
Anti-Linear Ubiquitin Antibody, clone LUB9
产品别名
Anti-Linear Ubiquitin Antibody, clone LUB9
Polyubiquitin-C, Ubiquitin
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Ubiquitin functions as a marker to indicate the fate of other proteins in the cell. It can be attached as a single molecule or as a polyubiquitin chain. Although ubiquitinated proteins are oftentimes tagged for degradation by the 20S proteosome, ubiquitination can also indicate alternative fates depending on the lysine residue that is involved in linking the ubiquitin chain to the target protein. Ubiquitin chains linked by Lys33 to kinase substrates such as AMP-activated protein kinases, (AMPKα1, BRSK1, MARK3, MARK4, and NUAK1), may activate or deactivate these proteins, supporting the role for uniquitin in regulating signaling. |
| Specificity【特异性】 | This antibody detects only Linear Ubiquitin. |
| Immunogen【免疫原】 | Ovalbumin-conjugated linear peptide corresponding to human Linear Ubiquitin. |
| Application【应用】 | Anti-Linear Ubiquitin Antibody, clone LUB9 | MABS451 is an antibody against Linear Ubiquitin Antibody for use in Western Blotting. Western Blotting Analysis: A representative lot detected Linear Ubiquitin in (M1-linked) ubiquitin chains (Yoshiteru, S. et al. (2013). EMBO. 32:2463-2476). Research Category Signaling Research Sub Category Signaling Neuroscience |
| Quality【质量】 | Evaluated by Western Blotting in recombinant protein Linear Polyubiquitin chains, K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein. Western Blotting Analysis: 1.0 µg/mL of this antibody detected 10 µg of Linear Polyubiquitin recombinant protein chains, bands were not detected in K48 Ub 2-7, K63 Ub 2-7, and K11-only Ubn-ubiquitinylated HM substrate protein. |
| Physical form【外形】 | Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | LUB9, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG2bκ |
| NCBI accession no.【NCBI登记号】 | NP_066289 |
| UniProt accession no.【UniProt登记号】 | P0CG48 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | Multiple bands observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
