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Anti-Lysine-specific demethylase 7 Antibody

产品编号:4109932
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4109932100 μG4860
产品别名

Anti-Lysine-specific demethylase 7 Antibody

Lysine-specific demethylase 7, JmjC domain-containing histone demethylation protein 1D

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Lysine-specific demethylase 7, also known as JmjC domain-containing histone demethylation protein 1D, and encoded by the gene JHDM1D/KDM7/KIAA1718, is an important histone demethylase particularly for brain development. JHDM1D specifically demethylates dimethylated ′Lys-9′ and ′Lys-27′ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ′Lys-20′ residue (H4K20Me1), thereby playing a central role in histone code. JHDM1D also specifically binds trimethylated ′Lys-4′ of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. JHDM1D also demethylates H3K9me2 in absence of H3K4me3 and JHDM1D has activity toward H4K20Me1 only when the nucleosome is used as a substrate and when not the histone octamer is used as substrate. JHDM1D is located in the nucleus and widely expressed but lowered expression is observed in glial cells and lymphoid cells. JHDM1D demonstrates tumor suppression by regulating angiogenesis factors when overexpression under starvation conditions in certain cancers, thus JHDM1D is being examined as a potential anti-cancer target.
Specificity【特异性】
This antibody is expected to cross react with two known isoforms of Lysine-specific demethylase 7 based upon immunogen design.
Immunogen【免疫原】
KLH-conjugated linear peptide corresponding to human Lysine-specific demethylase 7.
Application【应用】
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
Detect Lysine-specific demethylase 7 using this rabbit polyclonal antibody, Anti-Lysine-specific demethylase 7 Antibody validated for use in western blotting.
Quality【质量】
Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Lysine-specific demethylase 7 in 10 µg of HEK293 cell lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
mouse, giant panda, rhesus macaque, canine, marmoset, chimpanzee
technique(s)
western blot: suitable
NCBI accession no.【NCBI登记号】
NP_085150
UniProt accession no.【UniProt登记号】
Q6ZMT4
shipped in【运输】
wet ice
Gene Information
human ... JHDM1D(80853)
产品说明
Target description【目标描述】
~110 kDa observed. Uniprot describes two isoforms at 107 kDa (isoform 1) and 92 kDa (isoform 2).
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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