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Anti-NOD1/CARD4 Antibody, clone 021

产品编号:4111282
规格:clone 021, 1 mg/mL, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4111282100 μG5010
产品别名

Anti-NOD1/CARD4 Antibody, clone 021

Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
NOD1/CARD4, also known as Nucleotide-binding oligomerization domain-containing protein 1, or Caspase recruitment domain-containing protein 4, and encoded by the gene NOD1/CARD4, is an important apoptosis mediating protein that enhances caspase-9-mediated apoptosis. NOD1/CARD4 also mediates cellular responsiveness to intracellular bacterial LPS and forms an intracellular sensing system along with another protein called ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. NOD1/CARD4 is a homodimer that is found in the cytoplasm but also associated with the cell membrane in particular cells such as polarized epithelial cells. NOD1/CARD4 is expressed in many tissues including heart, skeletal muscle, and pancreas. As part of the innate immune system NOD1/CARD4 is part of a family of proteins that are responsible for the initial response of an organism to potentially harmful stressors, pathogens or tissue injury, and accordingly plays an essential role in the pathogenesis of many inflammatory processes, including some cardiovascular diseases.
Immunogen【免疫原】
Epitope: CARD domain
Recombinant protein corresponding to the CARD domain of human NOD1/CARD4.
Application【应用】
Flow Cytometry Analysis: 2 µg of this antibody from a representative lot detected NOD1/CARD4 in 1X10E6 Jurkat cells. This antibody was produced in collaboration with the Scripps Research Institute.
Research Sub Category
Immunoglobulins & Immunology
Anti-NOD1/CARD4 Antibody, clone 021 is an antibody against NOD1/CARD4 for use in western blotting & flow cytometry.
Research Category
Inflammation & Immunology
Quality【质量】
Evaluted by Western Blotting in human spleen tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected NOD1/CARD4 in 10 µg of human spleen tissue lysate.

This antibody was produced in collaboration with the Scripps Research Institute. For Scripps Research Institute Validation (Click Here)
Physical form【外形】
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
021, monoclonal
species reactivity
human
concentration【浓度】
1 mg/mL
technique(s)
flow cytometry: suitable
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_006083
UniProt accession no.【UniProt登记号】
Q9Y239
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
~125 kDa observed. The calculated molecular weight of this protein is 108 kDa, but has been observed at ~125 kDa in some cell lysates. An IgG heavy chain may be observed at 55 kDa
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
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