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Anti-NOTUM Antibody
| 产品编号： | 4111351 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-NOTUM Antibody
Protein notum homolog, NOTUM
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Protein notum homolog (NOTUM) is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by β-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway. In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein. |
| Immunogen【免疫原】 | KLH-conjugated synthetic peptide corresponding to the N-terminus of human NOTUM. Epitope: N-terminus |
| Application【应用】 | Research Category Signaling Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected NOTUM in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected NOTUM in mouse kidney cells. Anti-NOTUM Antibody is an antibody against NOTUM for use in western blotting, IHC & immunofluorescence. Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in human kidney tissue lysate. Western Blotting Analysis: 1 μg/mL of this antibody detected NOTUM in human kidney tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q6P988 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... NOTUM(147111) |
产品说明
| Target description【目标描述】 | ~73 kDa observed. Uncharacterized bands may be observed in some lysate(s). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 2 |
