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Anti-Pan-GRK Antibody, clone N145/20
产品别名
Anti-Pan-GRK Antibody, clone N145/20
G protein-coupled receptor kinase 5, G protein-coupled receptor kinase GRK5
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | G protein-coupled receptor kinases (GRK) are serine/threonine kinases that phosphorylate a variety of G-protein-coupled receptors (GPCRs), specifically activated forms, including adrenergic receptors, muscarinic acetylcholine receptors, dopamine receptors and opioid receptors. GRK receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. |
| Specificity【特异性】 | This antibody recognizes the C-terminus of GRK. This antibody cross reacts with GRK6 (Prof. J. Trimmer, University of California, Davis.). |
| Immunogen【免疫原】 | Recombinant protein corresponding to the C-terminus of mouse Pan-GRK. Epitope: C-terminus |
| Application【应用】 | Anti-Pan-GRK Antibody, clone N145/20 Cat. No. MABN615 is a highly specific mouse monoclonal antibody & that targets GRK & has been tested in western blotting. Research Category Neuroscience Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in mouse liver tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pan-GRK in 10 µg of mouse liver tissue lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Mouse liver tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | N145/20, monoclonal |
| species reactivity | mouse |
| technique(s) | western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_061357 |
| UniProt accession no.【UniProt登记号】 | Q8VEB1 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 68 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
