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Anti-phospho NR1 (Ser897) Antibody
| 产品编号： | 4112176 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho NR1 (Ser897) Antibody
glutamate receptor, ionotropic, N-methyl D-aspartate 1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, glutamate [NMDA] receptor subunit zeta-1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. |
| Specificity【特异性】 | This antibody recognizes NR1 when phosphorylated at Ser897. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to rat NR1 when phosphorylated at Ser897. Epitope: Phosphorylated Ser897 |
| Application【应用】 | This Anti-phospho NR1 (Ser897) Antibody is validated for use in WB, IP, IH for the detection of phospho NR1 (Ser897). Immunohistochemistry Analysis: 1:50 dilution from a previous lot detected NR1 in normal rat hippocampus. Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated NR1 from rat brain microsomal RIPA lysate. Western Blot Analysis: 2 µg/mL from a previous lot detected NR1 in Lambda phosphatase untreated and treated rat brain microsomal tissue lysate. Research Sub Category Signaling Neuroscience Research Category Neuroscience |
| Quality【质量】 | Evaluated by Western Blot in rat brain microsomal tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of rat brain microsomal tissue lysate. |
| Linkage【联系】 | Replaces: 06-641 |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Rat brain microsomal tissue lysate |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), human (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q05586 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~ 120 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
