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Anti-Phospho-LRP6-S1490 antibody produced in rabbit

产品编号:4112466
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
41124665400
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
liquid
species reactivity
mouse, rat, human
concentration【浓度】
0.429 mg/mL
technique(s)
western blot: 1:500-1:2000
UniProt accession no.【UniProt登记号】
O75581
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... LRP6(4040)
基本信息
General description【一般描述】
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
Immunogen【免疫原】
A synthetic phosphorylated peptide around S1490 of human LRP6.
Physical form【外形】
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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