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Anti-phospho-Peak Antibody (Tyr665)
| 产品编号： | 4112567 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-Peak Antibody (Tyr665)
Pseudopodium-enriched atypical kinase 1, Sugen kinase 269, Tyrosine-protein kinase SgK269
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Pseudopodium-enriched atypical kinase 1 (Peak1; KIAA2002, or sgk269) is a ubiquitous non-receptor tyrosine kinase that belongs to the NFK3 family. It interacts with actin filaments via its N-terminal actin-targeting region. It also modulates the activity of multiple cytoskeletal regulatory proteins such as paxillin, p130Cas, Erk, and Crk; and mediates cell proliferation and migration via the Ras/Raf/Erk and Src-p130Cas-Crk-Paxillin pathways. Peak1 may play an important role in the progression of tumors. |
| Specificity【特异性】 | This antibody recognizes Peak phosphorylated at Tyr665. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to human Peak phosphorylated at Tyr665. Epitope: Phosphorylated Tyr665 |
| Application【应用】 | Western Blot Analysis: A representative lot was used by an independent laboratory in 293T cells transfected with wildtype GFP-Peak. (Dr. Richard Klemke, University of California-San Diego.) This phospho-Peak antibody is validated for use in WB & Dot Blot for the detection of the phospho-Peak protein. |
| Quality【质量】 | Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins. Dot Blot (Specificity) Analysis: A representative lot blocked phospho-Peak (Tyr665) in modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins. |
| Analysis Note【分析说明】 | Affinity purified |
| Other Notes【其他说明】 | Control Modified and non modified peptides of phosphorylated and non-phosphorlyated Peak proteins |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | mouse (based on 100% sequence homology), orangutan (Sumatran; based on 100% sequence homology), porcine (based on 100% sequence homology), rat (based on 100% sequence homology) |
| technique(s) | dot blot: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_079052 |
| UniProt accession no.【UniProt登记号】 | Q9H792 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | 220 kDa calculated |
| 【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
