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Anti-phospho-SRPK2 (Ser497) Antibody
| 产品编号： | 4112672 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-phospho-SRPK2 (Ser497) Antibody
SRSF protein kinase 2, SFRS protein kinase 2, Serine/arginine-rich protein-specific kinase 2, SR-protein-specific kinase 2, SRSF protein kinase 2 N-terminal, SRSF protein kinase 2 C-terminal
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | SRPK2 is also known as SRSF protein kinase 2, SFRS protein kinase 2, and Serine/arginine-rich protein-specific kinase 2. SRPK2 is a kinase which is involved in the phosphorylation of SR splicing factors, and the regulation of splicing. SRPK2 also promotes neuronal apoptosis, plays an essential role in splicesomal B complex formation, and mediates hepatitis B virus (HBV) replication and core protein phosphorylation. SRPK2 is highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney. |
| Specificity【特异性】 | This antibody recognizes the protein kinase domain of SRPK2 phosphorylated at Ser497. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to the protein kinase domain of human SRPK2 (Ser497). Epitope: Protein kinase domain |
| Application【应用】 | Anti-phospho-SRPK2 (Ser497) Antibody is a highly specific rabbit polyclonal antibody, that targets SRPK & has been tested in western blotting. Research Category Signaling Research Sub Category Developmental Signaling |
| Quality【质量】 | Evaluated by Western Blotting in NIH3T3 cell lysate. Western Blotting Analysis: A 1:500 dilution of this antibody detected SRPK2 (Ser497) in 10 µg of NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control NIH3T3 cell lysate and Insulin treated NIH3T3 cell lysate |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | hamster, mouse, human |
| species reactivity (predicted by homology) | rat (based on 100% sequence homology), Xenopus (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_872633 |
| UniProt accession no.【UniProt登记号】 | P78362 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SRPK2(6733) |
产品说明
| Target description【目标描述】 | ~120 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~77 kDa and ~79 kDa Uniprot states 8 phosphorylation sites are known to exist. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
