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产品别名
Anti-pro-TRH
anti-thyrotropin-releasing hormone, anti-Ps4
基本信息
eCl@ss | 32160702 |
General description【一般描述】 | Pro-thyrotropin-releasing hormone (UniProt: P01150; also known as Pro-TRH, Prothyroliberin, TRH, TSH-releasing factor, Thyrotropin-releasing factor, TRF) is encoded by the Trh gene (Gene ID: 25569) in rat. TRH is a secreted hypothalamic protein that travels across the median eminence to the pituitary via the hypophyseal portal system. It functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. Pro-TRH (TRH-potentiating peptide: Ps4) is co-synthesized with TRH serves as a marker for TRH-containing neurons. Like TRH itself, pro-TRH is biologically active. |
Specificity【特异性】 | This polyclonal antibody detects Thyrotropin-releasing hormone-containing neurons in Rat Hypothalamus and spinal cord. |
Immunogen【免疫原】 | A linear peptide corresponding to 10 amino acids |
Application【应用】 | Anti-pro-TRH, Cat. No. ABN1658, is a highly specific rabbit polyclonal antibody, that targets pro- Thyrotropin-releasing hormone and has been tested in Immunofluorescence and Western Blotting. Research Category Neuroscience Immunofluorescence Analysis: A representative lot detected pro-TRH in median eminence of rat and L2 spinal cord tissues. (Courtesy of Dr. Martin Wessendorf at University of Minnesota). Immunofluorescence Analysis: A representative lot detected pro-TRH in rat brain stem & rat spinal cord tissues. (Wessendorf, M.W., et. al. (1990). J Histochem Cyotchem. 38(12):1859-77). |
Quality【质量】 | Evaluated by Western Blotting in rat hypothalamus tissue lysate. Western Blotting Analysis: A 1:500 dilution of this antibody detected pro-TRH in 10 µg of rat hypothalamus tissue lysate. |
Physical form【外形】 | Unpurified Rabbit polyclonal serum with 0.09% sodium azide. |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
biological source【生物来源】 | rabbit |
Quality Level【质量水平】 | 100 |
antibody form【抗体形式】 | serum |
antibody product type | primary antibodies |
clone【克隆】 | polyclonal |
species reactivity | rat |
species reactivity (predicted by homology) | mouse |
technique(s) | immunofluorescence: suitable western blot: suitable |
NCBI accession no.【NCBI登记号】 | NP_037178 |
UniProt accession no.【UniProt登记号】 | P01150 |
shipped in【运输】 | ambient |
产品说明
Target description【目标描述】 | ~29 kDa observed; 29.28 kDa calculated. Uncharacterized bands may be observed in some lysate(s). |
Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |