广州伟伯科技有限公司
您的位置:首页 > 产品中心 > Anti-Procadherin FAT1 Antibody, clone C257
产品搜索:

Anti-Procadherin FAT1 Antibody, clone C257

产品编号:4113161
规格:clone C257, from mouse
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4113161100 μG6020
产品别名

Anti-Procadherin FAT1 Antibody, clone C257

Cadherin family member 7, Cadherin-related tumor suppressor homolog, Protein fat homolog

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Procadherin FAT1 protein is a cell membrane bound protein that also has an active nuclear-translocation component that can alter specific gene expression and cell proliferation. Procadherin FAT1 is important in cell polarization and directed cell migration and also modulates cell-cell contact interactions. Procadherin FAT1 is expressed in epithelial, endothelial and smooth muscle cells and plays roles in their response to injury and is often highly induced after arterial injury and effects vascular smooth muscle cell growth and migration. Procadherin FAT1 is also important in cancer where it appears to function as both an oncogene and a tumor suppressor depending upon the cell context. Also recent research has shown that soluble FAT1 can be a novel biomarker candidate for such cancers as pancreatic cancer.
Immunogen【免疫原】
Recombinant protein corresponding to Human FAT1.
Application【应用】
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Procadherin FAT1 in 10 µg of FAT1 transfected MV3 cell lysate.
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Procadherin FAT1 in 10 µg of FAT1 transfected MDA-MB-231 and MDA-MB-468 cell lysate.
Immunoprecipitation Analysis: A representative lot immunoprecipitated Procadherin FAT1 in C257 cell lysate. (Courtesy of Dr. R. Thorne, U of Newcastle, AU.)
This Anti-Procadherin FAT1 Antibody, clone C257 is validated for use in Western Blotting and Immunoprecipitation for the detection of Procadherin FAT1.
Research Category
Apoptosis & Cancer
Quality【质量】
Evaluated by Western Blotting in FAT1 transfected NIH-3T3 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Procadherin FAT1 in 10 µg of FAT1 transfected NIH-3T3 cell lysate.
Physical form【外形】
Format: Purified
Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
Other Notes【其他说明】
Concentration: Please refer to lot specific datasheet.
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
C257, monoclonal
species reactivity
human
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
isotype【同位素/亚型】
IgG1κ
NCBI accession no.【NCBI登记号】
NP_005236
UniProt accession no.【UniProt登记号】
Q14517
shipped in【运输】
wet ice
产品说明
Target description【目标描述】
>260 kDa observed. Procadherin FAT1 is an extremely large cell surface receptor with a calculated MW of 506 kDa and it′s highly glycosolated. It may be difficult to resolve the protein by western blot. An uncharacterized band at 50 kDa and other lower MWs may be observed in some lysates.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 1
广州伟伯科技有限公司 版权所有 CopyRight ©2006-2024, All Rights Reserved
工信部备案号:粤ICP备08114744号   Page Run Time: 0.0123