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Anti-RIM 2 Antibody
| 产品编号： | 4113705 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-RIM 2 Antibody
Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 3
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM 1 and RIM 2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM 1, RIM 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner. |
| Specificity【特异性】 | This antibody may recognize many isoforms and is predicted to have no cross-reactivity to other RIM proteins. |
| Immunogen【免疫原】 | Epitope: center region KLH-conjugated synthetic peptide corresponding to the center region of human RIM 2. |
| Application【应用】 | Anti-RIM 2 Antibody is an antibody against RIM 2 for use in western blotting, IHC & immunofluorescence. Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected RIM 2 in human brain tissue. Immunofluorescence Analysis: 20 μg/mL from a representative lot detected RIM 2 in human brain cells. Research Category Neuroscience Research Sub Category Developmental Neuroscience |
| Quality【质量】 | Evaluated by Western Blotting in rat brain tissue lysate with and without blocking peptide. Western Blotting Analysis: 1 μg/mL of this antibody detected RIM 2 in rat brain tissue lysate with and without blocking peptide. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. Antigen Affinity Purified |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, human |
| technique(s) | immunofluorescence: suitable immunohistochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q9UQ26 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | ~86 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing ranging between ~31 kDa and ~160 kDa |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
