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Anti-Syntaphilin Antibody

产品编号:4114950
规格:from rabbit, purified by affinity chromatography
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4114950100 μG5850
产品别名

Anti-Syntaphilin Antibody

Syntaphilin

基本信息
eCl@ss
32160702
NACRES
NA.41
General description【一般描述】
Syntaphilin (SNPH) is a single-pass membrane protein that was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.
Immunogen【免疫原】
Epitope: center region
KLH-conjugated synthetic peptide corresponding to the center region of human Syntaphilin.
Application【应用】
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected Syntaphilin in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected Syntaphilin in human brain cells.
Anti-Syntaphilin Antibody is an antibody against Syntaphilin for use in western blotting, IHC & immunofluorescence.
Quality【质量】
Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected Syntaphilin in rat brain tissue lysate.
Physical form【外形】
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Antigen Affinity Purified
Other Notes【其他说明】
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
产品性质
biological source【生物来源】
rabbit
Quality Level【质量水平】
100
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
purified by【纯化方式】
affinity chromatography
species reactivity
human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt accession no.【UniProt登记号】
O15079
shipped in【运输】
wet ice
Gene Information
human ... SNPH(9751)
产品说明
Target description【目标描述】
~86 kDa observed. Uncharacterized bands may be observed in some lysate(s). Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE.
Storage and Stability【储存及稳定性】
Stable for 1 year at 2-8°C from date of receipt.
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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