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Anti-Syntaxin antibody, Mouse monoclonal

产品编号:4114953
规格:clone HPC-1, purified from hybridoma cell culture
包装规格:25 μL,100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411495325 μL1970
4114953100 μL4720
产品性质
Quality Level【质量水平】
200
antibody form【抗体形式】
purified from hybridoma cell culture
clone【克隆】
HPC-1, monoclonal
form【形式】
liquid
species reactivity
monkey, mouse, human, rat, dog, bovine
concentration【浓度】
~1 mg/mL
technique(s)
immunoblotting: 0.25-0.5 μg/mL using human neuroblastoma SHSY5Y cell lysate.
isotype【同位素/亚型】
IgG1
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
基本信息
General description【一般描述】
Syntaxins are a family of membrane-integrated proteins that are instrumental in exocytosis of vesicles.6 The syntaxin family consists of 15 genes in mammals and 7 in yeast, and there are syntaxin-like sequences in all eukaryotes examined.7 All mammalian syntaxins, with the exception of syntaxin 11, are transmembrane proteins anchored by their C-terminal tails.7
Syntaxin-1(also known as HPC-1 antigen or Stx1),8-9 a 35 kDa molecule with carboxyl-terminal membrane anchor, is a synaptic protein identified by its ability to interact with the synaptic vesicle protein synaptotagmin
Specificity【特异性】
Monoclonal Anti-Syntaxin antibody specifically recognizes membrane protein syntaxin, expressed predominantly in neuronal tissues.2,3 The antibody reacts with syntaxin from human, mouse and rat origin. The antibody has also been used to isolate syntaxin cDNA clones by screening a λgt 11 library from rat hippocampus.3
Application【应用】
The antibody may be used in various immunochemical techniques including Immunoblotting (~35 kDa), Immunohistochemistry4 and Immunofluorescence5.
Biochem/physiol Actions【生化/生理作用】
Syntaxin-1 protein is an essential component of the synaptic vesicle soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and is essential for neurotransmission.10 It forms a four-helical bundle complex with proteins SNAP-25 and VAMP2 that drives fusion of vesicular and plasma membranes.6,11
Physical form【外形】
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog  our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
nwg
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