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Anti-TMEM173/STING Antibody, clone 1B1.1
产品别名
Anti-TMEM173/STING Antibody, clone 1B1.1
Stimulator of interferon genes protein, hSTING, Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, hMITA, Transmembrane protein 173
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
General description【一般描述】 | TMEM173/STING, also known as STING, or Endoplasmic reticulum interferon stimulator, ERIS, Mediator of IRF3 activation, MMITA or Transmembrane protein 173, and encoded by the gene TMEM173/ERIS/MITA/STING, is a facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferons. STING acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol. Upon binding STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. STING also mediates cell death signaling via the activation of the ERK pathway. STING is found in multiple intracellular locations including the endoplasmic reticulum, plasma cell membrane, mitochondrion outer membrane, and perinuclear regions. STING is expressed in the B-cell lineage both immature and mature B cells but not plasma cells. Mutations in STING cause defects in innate immunity and compromised immune health. |
Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human TMEM173/STING. |
Application【应用】 | Anti-TMEM173/STING Antibody, clone 1B1.1 | MABF223 is an antibody against TMEM173/STING Antibody for use in Western Blotting. |
Quality【质量】 | Evaluated by Western Blotting in Jurkat cell lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected TMEM173/STING in 10 µg of Jurkat cell lysate. |
Physical form【外形】 | Protein G Purified Format: Purified |
Other Notes【其他说明】 | Concentration: Please refer to lot specific datasheet. |
产品性质
Quality Level【质量水平】 | 100 |
biological source【生物来源】 | mouse |
antibody form【抗体形式】 | purified antibody |
antibody product type | primary antibodies |
clone【克隆】 | 1B1.1, monoclonal |
species reactivity | human |
technique(s) | western blot: suitable |
isotype【同位素/亚型】 | IgG1κ |
NCBI accession no.【NCBI登记号】 | NP_938023 |
UniProt accession no.【UniProt登记号】 | Q86WV6 |
shipped in【运输】 | wet ice |
Gene Information | human ... TMEM173(340061) |
产品说明
Target description【目标描述】 | ~37 kDa observed |
【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 1 |