您的位置：首页 > 产品中心 > Anti-TMEM106B Antibody, clone TME-N 6F2
Anti-TMEM106B Antibody, clone TME-N 6F2
产品别名
Anti-TMEM106B Antibody, clone TME-N 6F2
Transmembrane protein 106B, TMEM106B
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Transmembrane protein 106B (TMEM106B) is a single-pass type II membrane protein present in endosomal and lysosomal membranes, and is highly expressed in the frontal cortex. Increased TMEM106B expression in the brain may be linked to mechanisms of disease in frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. |
| Specificity【特异性】 | This antibody recognizes the N-terminus of TMEM106B. |
| Immunogen【免疫原】 | Epitope: N-terminus Recombinant protein corresponding to the N-terminus of human TMEM106B. |
| Application【应用】 | Research Category Neuroscience Anti-TMEM106B, clone TME-N 6F2 detects levels of TMEM106B proteins & has been published & validated for use in WB & IF. Immunofluorescence Analysis: A 1:50 dilution from a representative lot detected TMEM106B in rat cerebellum tissue. Research Sub Category Neurodegenerative Diseases |
| Quality【质量】 | Evaluated by Western Blot in human cortex tissue lysate. Western Blot Analysis: 1 µg/mL of this antibody detected TMEM106B in 10 µg of human cortex tissue lysate. |
| Physical form【外形】 | Format: Purified Purified rat monoclonal IgG2c in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Protein G Purified |
| Analysis Note【分析说明】 | Control Human cortex tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | rat |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | TME-N 6F2, monoclonal |
| species reactivity | rat, human |
| technique(s) | immunofluorescence: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_001127704 |
| UniProt accession no.【UniProt登记号】 | Q9NUM4 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... TMEM106B(54664) |
产品说明
| Target description【目标描述】 | ~30 kDa observed (At higher antibody concentrations, this protein may be observed at ~45 kDa). This protein may be observed at ~50 kDa due to glycosylation (Lang, C. M., et al. (2012). J Biol Chem. 287(23):19355-19365.). |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
