Anti-Tyrosine Hydroxylase antibody, Mouse monoclonal

NA.44

Anti-Tyrosine Hydroxylase antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma TH-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified rat Tyrosine Hydroxylase. Tyrosine Hydroxylase (TH) also known as tyrosine 3- monooxygenase, is encoded by the gene mapped to human chromosome 11p15.5. It is a tetrameric enzyme composed of four subunits. Four TH Isoforms were identified in humans.

purified rat Tyrosine Hydroxylase

Anti-Tyrosine Hydroxylase antibody, Mouse monoclonal has been used in various immunochemical techniques including immunoblotting, immunohistochemistry, immunofluorescence and immunoprecipitation.

Tyrosine Hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-dopa) in brain and adrenal medulla which is the initial and rate limiting step of the neurotransmitters and hormones catecholamines (dopamine, norepinephrine and epinephrine) biosynthesis. Therefore, TH plays a key role in the physiology of adrenergic neurons. Tyrosine Hydroxylase (TH) deficiency is associated with the development of wide variety of phenotypic spectrum such as several types of dystonia, early-onset of Parkinson′s, cerebral palsy or spastic paraplegia and both primary and secondary deficiencies of cerebrospinal fluid (CSF) neurotransmitter metabolites.

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

200

mouse

purified immunoglobulin

primary antibodies

TH-2, monoclonal

buffered aqueous solution

bovine, mouse, rabbit, guinea pig, sheep, human, rat

~1.0 mg/mL

immunoblotting: 0.25-0.5 μg/mL using whole extracts of rat PC-12 cells.

IgG1

dry ice

−20℃

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12 - Non Combustible Liquids

WGK 1