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Anti-ULK1 (N-terminal) antibody produced in rabbit

产品编号:4115823
规格:affinity isolated antibody
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4115823100 μL5250
产品别名

Anti-ULK1 (N-terminal) antibody produced in rabbit

ATG1A

hATG1

Unc51.1

UNC51

ATG1

产品性质
biological source【生物来源】
rabbit
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
affinity isolated antibody
antibody product type
primary antibodies
clone【克隆】
polyclonal
form【形式】
buffered aqueous solution
mol wt【分子量】
112 kDa
species reactivity (predicted by homology)
bovine, guinea pig, rabbit, horse, human, mouse, canine, rat
concentration【浓度】
0.5 mg/mL
technique(s)
western blot: 1 μg/mL
NCBI accession no.【NCBI登记号】
NM_003565
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... ULK1(57396)
基本信息
General description【一般描述】
ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
Immunogen【免疫原】
Synthetic peptide directed towards the N-terminal region of Human ULK1
Sequence【序列】
Synthetic peptide located within the following region: PEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTL
Physical form【外形】
Supplied at 0.5 mg/ml in phosphate-buffered saline, 0.09% sodium azide
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
nwg
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