Anti-VE-Cadherin Antibody (CD144), clone BV9

32160702

NA.41

Also known as CD144, human Vascular Endothelial (VE)-cadherin is a calcium-dependent adhesion molecule strictly located at cell to cell junctions. VE-cadherin is present in all types of endothelium (veins, arteries, capillary and large vessels). Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherins are reported to play an important role in angiogeneis and in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha catenin forming a link to the cytoskeleton.

This antibody recognizes the extracellular domain of VE-Cadherin.

Recombinant protein corresponding to the extracellular domain of human VE-Cadherin.
Epitope: Extracellular domain.

Research Category
Cell Structure
This VE-Cadherin antibody is validated for use in ICC & Enzyme Assay for the detection of the VE-Cadherin protein.
Activity Assay Analysis: A representative lot from an independent laboratory increased endothelial permeability, inhibited the organization of vasclular-like structures, and prevented the protective effect of VEGF against apoptosis in endothelial cells.
Research Sub Category
Adhesion (CAMs)

Evalutated by Immunocytochemistry in HUVEC cells.

Immunocytochemistry Analysis: 1 µg/mL of this antibody detected VE-Cadherin in HUVEC cells.

Purified mouse monoclonal IgG2aκ in buffer containing PBS without 0.05% sodium azide.
Format: Purified
Protein G Purified

Control
HUVEC cells

100

mouse

purified antibody

primary antibodies

BV9, monoclonal

human

activity assay: suitable
immunocytochemistry: suitable

IgG2aκ

NP_001786

P33151

wet ice

human ... CDH5(1003)

88 kDa calculated

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

12 - Non Combustible Liquids

WGK 2