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Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1
产品别名
Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1
Yorkie homolog, Yes-associated protein, Yap65
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | The YAP1 gene encodes a protein that binds to the SH3 (Src homology 3) domain of the Yes proto-oncogene product. As a transcriptional regulator, it can act as a coactivator and a corepressor, and serves as a critical downstream regulatory target in the Hippo signaling pathway. Additionally, it plays a critical role in regulating organ size and in tumor suppression by restricting proliferation and promoting apoptosis. The human YAP1 gene is well conserved among higher eukaryotes, but may not be conseved in yeast. Yes-associated protein expression is almost ubiquitous in adult human tissues, but is not detectable in peripheral blood leukocytes. |
| Immunogen【免疫原】 | GST-tagged recombinant protein corresponding to human Yes-associated protein (YAP1). |
| Application【应用】 | Research Sub Category Cell Cycle, DNA Replication & Repair Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Yes-associated protein (YAP1) in HeLa and A431 cells. Research Category Epigenetics & Nuclear Function Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1 detects level of Yes-associated protein (YAP1) & has been published & validated for use in WB & IC. |
| Quality【质量】 | Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Yes-associated protein (YAP1) in 10 µg of HeLa cell lysate. |
| Physical form【外形】 | Purified mouse monoclonal IgG1κ supernatant containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Format: Purified Protein G Purified |
| Analysis Note【分析说明】 | Control Hela cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 4D11.1, monoclonal |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | NP_001123617 |
| UniProt accession no.【UniProt登记号】 | P46937 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... YAP1(10413) |
产品说明
| Target description【目标描述】 | ~65 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
