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Beta D-1 (47 aa) human

产品编号:4116755
规格:recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
包装规格:20 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
411675520 μG4820
产品别名

Beta D-1 (47 aa) human

beta-Defensin-1

DEFB1

基本信息
NACRES
NA.32
General description【一般描述】
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36a.a.), a propeptide region. b-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.
Chemical structure: peptide
Biochem/physiol Actions【生化/生理作用】
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. Recombinant human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.
Sequence【序列】
GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK
Physical form【外形】
Lyophilized from 10 mM Sodium Citrate, pH 4.0.
Reconstitution【重悬】
Centrifuge the vial prior to opening. Reconstitute in 10 mM Acetic Acid to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥98% (HPLC)
≥98% (SDS-PAGE)
form【形式】
lyophilized
mol wt【分子量】
5.0 kDa
packaging【包装】
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities【杂质】
<0.1 EU/μg endotoxin, tested
color【颜色】
white to off-white
UniProt accession no.【UniProt登记号】
P60022
antibiotic activity spectrum【抗生素抗菌谱】
fungi
mycobacteria
viruses
Mode of action【作用机制】
cell membrane | interferes
shipped in【运输】
wet ice
storage temp.【储存温度】
−20℃
Gene Information
human ... DEFB1(1672)
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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