BPTF (2796-2907) GST tag human

human

expressed in E. coli

≥80% (SDS-PAGE)

liquid

40.1 kDa (2796-2907 aa + NT GST Tag)

pkg of 100 μg
pkg of 20 μg

Q12830

dry ice

−70℃

human ... BPTF(2186)

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BPTF is the largest component of the NURF chromatin remodeling complex. It includes adjacent PHD and bromodomains which recognize trimethylation of H3K4 or acetylation of lysines in histone 4, respectively. BPTF is an essential regulator of gene expression in early mouse embryos, and its knock-out is embryonic lethal. Duplication of the BPTF gene has been suggested to increase proliferation of cultured cancer cells, and aberrant BPTF copy numbers were found in 42% of the “NCI-60” panel of 60 human cancer cell lines. This protein product contains the bromodomain of BPTF.

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

GHS07

Warning

H317 - H319 - H412

P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1

13 - Non Combustible Solids

WGK 3