BRD3 (24-144) GST tag human

human

expressed in E. coli

≥95% (SDS-PAGE)

liquid

41.2 kDa (24-144 aa + NT GST Tag)

pkg of 100 μg
pkg of 20 μg

NM_007371

Q15059

dry ice

−70℃

human ... BRD3(8019)

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD3 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.

GHS07

Warning

H317 - H319 - H412

P273 - P280 - P305 + P351 + P338 - P333 + P313 - P337 + P313

Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1

13 - Non Combustible Solids

WGK 3