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BRD4 (49-170) GST tag human

产品编号:4116938
规格:recombinant, expressed in E. coli, ≥82% (SDS-PAGE)
包装规格:100 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
4116938100 μG8830
产品别名

BRD4 (49-170) GST tag human

HUNKI

CAP

Bromodomain containing 4

HUNK1

MCAP

基本信息
NACRES
NA.32
General description【一般描述】
BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.
Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 49-170 with N-terminal GST-tag, MW = 41.4kDa, expressed in an Escherichia coli expression system.
Biochem/physiol Actions【生化/生理作用】
BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease. This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis. BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.
产品性质
biological source【生物来源】
human
recombinant【重组】
expressed in E. coli
Assay【测定】
≥82% (SDS-PAGE)
form【形式】
aqueous solution
mol wt【分子量】
41.4 kDa
packaging【包装】
pkg of 100 μg
NCBI accession no.【NCBI登记号】
NM_058243
UniProt accession no.【UniProt登记号】
O60885
shipped in【运输】
dry ice
storage temp.【储存温度】
−70℃
Gene Information
human ... BRD4(23476)
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 2
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