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BRD4, BD1, BD2 (49-460) GST tag human
| 产品编号： | 4116940 |
| 规格： | recombinant, expressed in E. coli, ≥80% (SDS-PAGE) |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
BRD4, BD1, BD2 (49-460) GST tag human
HUNKI
CAP
Bromodomain containing 4
HUNK1
MCAP
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker. Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_ NM_058243) amino-acids 49-460 with N-terminal GST-tag, MW = 73.3kDa, expressed in an Escherichia coli expression system. |
| Biochem/physiol Actions【生化/生理作用】 | BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease. This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis. BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥80% (SDS-PAGE) |
| form【形式】 | aqueous solution |
| mol wt【分子量】 | 73.3 kDa |
| packaging【包装】 | pkg of 100 μg |
| NCBI accession no.【NCBI登记号】 | NM_058243 |
| UniProt accession no.【UniProt登记号】 | O60885 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... BRD4(23476) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
