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C-176
产品别名
314054-00-7
C-176
C 176
Sting inhibitor 1
Sting inhibitor C-176
N-(4-Iodophenyl)-5-nitro-2-furancarboxamide
N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide
C176
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H7IN2O4 |
| Molecular weight | 358.09 |
| MDL number | MFCD00784208 |
| Biochem/physiol Actions【生化/生理作用】 | C-176 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-176 inhibits STING-mediated IFNβ reporter activity (IC50 <50 nM) without affecting RIG-I, and blocks (1 μM) downstream TBK1 phosphorylation induction by STING agonist CMA (1.4 h) in mSTING-expressing HEK293T cells. C-176 markedly reduces CMA-induced serum IL-6 & type I IFNs in mice (by ≥85% 4 h post CMA; 750 nmol C-176/mouse i.p. 1 or 4 h prior to 224 mg/kg CMA) and significantly ameliorates the autoinflammatory severity in Trex1−/− mice. |
产品性质
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to very dark gray |
| solubility【溶解性】 | DMSO: 2 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(NC1=CC=C(I)C=C1)C2=CC=C([N+]([O-])=O)O2 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
