CAR-LBD (101-348), GST tagged human

NA.26

The gene encoding this protein is localized on human chromosome 1q23.3.

It forms a complex with phosphatase 2A, heat shock protein 90 (Hsp90) and cytosolic CAR retention protein in the cytoplasm. On activation, it translocates to the nucleus and modulates the expression of genes associated with drug metabolism. The protein regulates transforming growth factor-β (TGF-β) signaling.
The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively active, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Clear and colorless frozen liquid solution

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

human

expressed in E. coli

≥70% (SDS-PAGE)

frozen liquid

~55.3 kDa

pkg of 10 μg

avoid repeated freeze/thaw cycles

100  μg/mL

clear
colorless

NM_005122

Q14994

dry ice

−70℃

human ... NR1I3(9970)

10 - Combustible liquids

WGK 1