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CD273 human
| 产品编号： | 4117189 |
| 规格： | recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) |
| 包装规格： | 10 μG，50 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
CD273 human
PDCD1LG2
Butyrophilin B7-DC
PDL2
PDCD1 ligand 2
PDCD1L2
基本信息
| NACRES | NA.32 |
| General description【一般描述】 | Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as butyrophilin B7-DC or CD antigen CD273. It belongs to the immunoglobulin superfamily or BTN/MOG family. The gene encoding CD273 is localized on human chromosome 9p24.1. |
| Biochem/physiol Actions【生化/生理作用】 | The expression of programmed cell death 1 ligand 2 (PD-L2) or CD antigen 273 (CD273) is up-regulated by interferon-γ (IFNG/IFN-γ) stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with colony-stimulating factor-2 (CSF2) and interleukin-4 (IL-4). PD-L2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. |
| Physical form【外形】 | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
| Reconstitution【重悬】 | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃. |
产品性质
| biological source【生物来源】 | human |
| recombinant【重组】 | expressed in HEK 293 cells |
| tag【标签】 | 6-His tagged (C-terminus) |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| form【形式】 | lyophilized |
| mol wt【分子量】 | calculated mol wt 23.4 kDa observed mol wt 35-48 kDa (DTT-reduced. Protein migrates due to glycosylation. Leu 20 is the predicted N-terminus.) |
| packaging【包装】 | pkg of 10 μg pkg of 50 μg |
| UniProt accession no.【UniProt登记号】 | Q9BQ51 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... PDCD1LG2(80380) |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
