CD319/SLAMF7/CRACC human

NA.32

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates natural killer (NK) cell activation through a SH2 domain containing 1A (SH2D1A)-independent extracellular signal-regulated extracellular signal-regulated kinases (ERK) mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation. SLAM F7 (signaling lymphocytic activation molecule F7) receptors are expressed on immune cells such as activated T cells, most B cells, antibody-producing plasma cells and natural killer cell and also on myeloid cells. The SLAMF7 gene is mapped to human chromosome 1q23.3.

SLAMF7 (signaling lymphocytic activation molecule F7) is considered as a self-ligand which identifies another SLAMF7 expressed on the cell. Apart from immune cells, SLAMF7 is highly expressed on multiple myeloma cells.

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

human

expressed in HEK 293 cells

6-His tagged (C-terminus)

≥95% (SDS-PAGE)

lyophilized

calculated mol wt 23.2 kDa
observed mol wt 33-48 kDa (DTT-reduced. Protein migrates due to glycosylation. Ser 23 is the predicted N-terminus.)

pkg of 10 μg
pkg of 50 μg

<1 EU/μg endotoxin (LAL test)

Q9NQ25

wet ice

−20℃

human ... SLAMF7(57823)

11 - Combustible Solids

WGK 3