dPEG^®₁₂-SATA (S-acetyl-dPEG^®₁₂-NHS ester)

C₃₃H₅₉NO₁₇S

773.88

MFCD21363255

329823963

NA.22

dPEG^®₁₂-SATA (S-acetyl-dPEG^®₁₂-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG^® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG^®₁₂-SATA to install a protected thiol connected to the molecule via the dPEG^® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG^® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG^®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

>90%

solid or viscous liquid

reagent type: chemical modification reagent
reactivity: amine reactive
reagent type: cross-linking reagent

shape: linear
functionality: monofunctional

ambient

−20℃

O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O)ON1C(CCC1=O)=O

13 - Non Combustible Solids

WGK 3