EED (1-441) human

NA.32

Polycomb protein Embryonic Ectoderm Development (EED) is a WD repeat containing member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. EED is an established transcriptional repressor, as a novel NIPP1 interactor. NIPP1 only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and COOH-terminal thirds of NIPP1. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common EED mRNA. The extra sex combs (esc) gene of Drosophila and its mammalian homologue embryonic ectoderm development (EED) play pivotal roles in establishing Polycomb-group (Pc-G) mediated transcriptional silencing of regulatory genes during early development. EED/Sox2 regulatory loop contributes to the maintenance of self-renewal in embryonic stem (ES) cells by controlling histone methylation and acetylation. EED has been defined by the inability of embryos homozygous for certain c deletions to develop beyond the early stages of gastrulation.

50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.

human

expressed in E. coli

≥95% (SDS-PAGE)

liquid

53.5 kDa (1- 441 aa + NT His Tag)

pkg of 25 μg

O75530

dry ice

−70℃

human ... EED(8726)

13 - Non Combustible Solids

WGK 3